UFC London predictions: Can Sean Brady change the guard vs. ex-champ Leon Edwards?

The UFC is back in London this week with a two former champions in fights at the top of the card.

UFC Fight Night 255 (ESPN+) takes place Saturday at The O2 in London.

Get pick results from our 11 editors, writers, radio hosts and videographers, as well as additional analysis, below.

Morgan Charriere vs. Nathaniel Wood

Records: Charriere (20-10-1 MMA, 2-1 UFC), Wood (20-6 MMA, 8-3 UFC)

Past five: Charriere 4-1, Wood 4-1

Division: Featherweight

Rankings: None

Odds (as of 03.21.25): Charriere -140, Wood +120

Junkie pick results: Wood 6, Charriere 5

Chris Duncan vs. Jordan Vucenic

Records: Duncan (12-2 MMA, 3-1 UFC), Vucenic (13-3 MMA, 0-1 UFC)

Past five: Duncan 4-1, Vucenic 4-1

Division: Lightweight

Rankings: None

Odds (as of 03.21.25): Duncan +350, Vucenic -455

Junkie pick results: Vucenic 7, Duncan 4

Molly McCann vs. Alexia Thainara

Records: McCann (14-7 MMA, 7-6 UFC), Thainara (11-1 MMA, 0-0 UFC)

Past five: McCann 2-3, Thainara 5-0

Division: Women’s strawweight

Rankings: None

Odds (as of 03.21.25): McCann +180, Thainara -220

Junkie pick results: Thainara 7, McCann 4

Kevin Holland vs. Gunnar Nelson

Records: Holland (26-13 MMA, 13-10 UFC), Nelson (19-5-1 MMA, 10-5 UFC)

Past five: Holland 1-4, Nelson 3-2

Division: Welterweight

Rankings: None

Odds (as of 03.21.25): Holland +100, Nelson -120

Junkie pick results: Nelson 8, Holland 3

Jan Blachowicz vs. Carlos Ulberg

Records: Blachowicz (29-10-1 MMA, 12-7-1 UFC), Ulberg (12-1 MMA, 7-1 UFC)

Past five: Blachowicz 2-2-1, Ulberg 5-0

Division: Light heavyweight

Rankings: Blachowicz No. 6, Ulberg No. 9

Odds (as of 03.21.25): Blachowicz +235, Ulberg -290

Junkie pick results: Blachowicz 6, Ulberg 5

Leon Edwards vs. Sean Brady

Records: Edwards (22-4 MMA, 14-3 UFC), Brady (17-1 MMA, 7-1 UFC)

Past five: Edwards 4-1, Brady 4-1

Division: Welterweight

Rankings: Edwards No. 2, Brady No. 7

Odds (as of 03.21.25): Edwards +130, Brady -155

Junkie pick results: Brady 6, Edwards 5

Preliminary card picks

Although they don’t count toward the standings, MMA Junkie staff members still pick the fights on the prelims. Here are the results:

• Jai Herbert vs. Chris Padilla: Padilla 6, Herbert 5
• Felipe dos Santos vs. Lone’er Kavanagh: Kavanagh 9, dos Santos 2
• Mick Parkin vs. Marcin Tybura: Tybura 6, Parkin 5
• Christian Leroy Duncan vs. Andrey Pulyaev: Duncan 10, Pulyaev 1
• Shauna Bannon vs. Puja Tomar: Bannon 10, Tomar 1
• Nathan Fletcher vs. Caolan Loughran: Loughran 6, Fletcher 5
• Kaue Fernandes vs. Guram Kutateladze: Kutateladze 10, Fernandes 1

Check out all the main card picks below.

(Click here to open a PDF of the staff picks grid in a separate window.)

For more on the card, visit MMA Junkie’s event hub for UFC Fight Night 255.

This article originally appeared on MMA Junkie: UFC London predictions: Can Sean Brady change the guard vs. ex-champ Leon Edwards?